Scavenge the Free Radicals Oxidizing Your Body

Coenzyme Q10… Alpha Lipoic Acid… Green Tea Polyphenols… Vitamin C & Vitamin E

Maduronol has Five Unique and High Performing Ingredients Specifically Chosen to Support and Recharge One Another In the Fight Against Oxidation

Glutathione is your body’s way of pulling out the “antioxidant big guns” as studies show it can not only donate electrons to eliminate oxidative enemies but also directly scavenge the metals in the body that create the oxidative damage.

CoQ10… Alpha Lipoic Acid… Green Tea Polyphenols… Vitamin C & Vitamin E

Support Circulation & Blood Vessel Function

Cigar smoking directly hampers the operation of the innermost layer of your arteries. This endothelium is the layer between the blood flowing inside the vessel and the wall of the vessel. The endothelium is essential for production of the delightful chemical known as nitric oxide.  Nitric oxide is responsible for causing vessels to dilate and expand, and when the endothelium is not working optimally – like when you smoke cigars - it’s not able to relax and dilate. 

That’s why Maduronol uses three powerful and synergistic compounds to support blood vessel function:

Red Grape Seed & Skin Extract, Alpha Lipoic Acid & Green Tea Extract 

Red Wine Polyphenols – the phenolic compounds derived from grape seed and skin dramatically support the function of blood vessels – even while smoking.

Published in the Journal of the American College of Nutrition, this study took healthy volunteers and had them smoke a single cigarette – which induced immediate and significant vessel constriction (a decrease in flow mediated dilation, FMD) which remained significantly decreased for an entire hour after the single cigarette.

But if a participant drank dealcoholized red wine or regular red wine while smoking the single cigarette, the flow mediated dilation was preserved and unchanged.  

This means the effect of the red wine (with or without alcohol) was so strong that the researchers couldn’t tell the difference between the smokers and non-smokers.  A similar effect was also published in the Journal of American Medicine in 2017 (https://www.amjmed.com/article/S0002-9343(16)30912-3/pdf).  It was a mystery what was causing the vessels to maintain function in the presence of smoking, until another group discovered the secret:

Red Wine Polyphenols actively bind to the estrogen receptors on the endothelium of blood vessels (yes - even you men have estrogen receptors) and induce the cells to continue producing nitric oxide – causing them to dilate.

And that’s why I have the same polyphenols in a dose of Maduronol as glass of red wine (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2903024/ - 200mg polyphenols)

Alpha Lipoic Acid & Green Tea Extract are  the final pillars of support for blood vessel function with Maduronol.  ALA is a natural antioxidant, as we’ve already discussed, and we use a broad extract of Green Tea polyphenols and catechins to ensure maximal support of blood vessel function.

Support Healthy Blood Pressure Already within Normal Ranges

The large dose of nicotine in cigars is what creates the feeling of relaxation, but it significantly raises your blood pressure by increasing cardiac output while constricting your blood vessels.

But because of the tremendous flavanol, polyphenol and catechin support that Maduronol offers for  blood vessel function and Nitric Oxide production, this support may also extend to supporting blood pressure that’s already within normal ranges.

At Maduronol we don’t rely on a single ingredient approach but employ a powerful combination of Red Grape Extract, Pomegranate Extract, Green Tea Catechins and Vitamin E to support your cigar smoking bad self.

Help Fight Systemic Immune Activation & Irritation in the Body

Once the oxidative damage hits the lining of your arteries – making them leaky and porous – while it’s oxidizing particles in the blood, these particles can embed and stick to the inside the walls your arteries, causing irritation and inefficient function.

Irritation of  of the blood vessels is a complex process, but it begins with the activation of the dramatically named, Inflammasome.  Oxidized LDL crystals and other signals cause the inflammasome to assemble and begin production of a of small, secreted proteins called cytokines.  When you have local irritation in a blood vessel, the first signal is known as Interleukin-1 (IL-1 for short)https://academic.oup.com/eurheartj/article-abstract/40/Supplement_1/ehz748.0689/5597923?redirectedFrom=fulltext

And that leads to production of the cytokine known as Interleukin 6 (IL-6 for short). 

IL-6 can further increase the permeability or ‘leakiness’ of your blood vessels, allowing more oxidized particles to infiltrate, recruiting more immune cells to increase the irritation and cause further blood vessel dysfunction by reducing the production of nitric oxide.  

And this cascade of inflammasome activation leading to production of IL-1 and IL-6 is the primary driver for increasing levels of C-Reactive Protein, CRP – a protein produced by the liver and serves as an excellent marker of systemic inflammation.  

To combat this systemic immune activation and blood vessel irritation, Maduronol uses six powerful ingredients to supports healthy  immune function:

Vitamin D, Pomegranate Extract, Turmeric: Curcumin & Alpha Lipoic Acid

Vitamin D

Vitamin D is interesting in that we get the majority of it from the sun exposure.  Your skin converts UVB into Vitamin D3, or cholecalciferol, and it’s absolutely vital for proper immune function.

So how much sun are you getting?  Do you know your Vitamin D3 levels?

 A study run by Fred Hutch Cancer Center evaluated women who were taking Vitamin D and exercising regularly for a year.  They also compared this group of women to those who take a placebo for a year while exercising for the same amount.

What they found is that those who were taking Vitamin D and lost 5-10% of their bodyweight, they lowered their inflammatory cytokine levels of IL-6 by 37% while those taking the placebo and losing the same amount of bodyweight only had an IL-6 reduction of 17%.

Taken together with many other studies there’s a tremendous association with levels of Vitamin D and lowered levels of inflammation, but we need to be careful because association does not mean causation.

It seems evident there is a clear association between blood levels of Vitamin D and many factors related to cardiovascular health, but the mechanism, the direct reason why Vitamin D can regulate inflammation has only been recently uncovered.

It turns out that Vitamin D can bind to the pre-cursors of the inflammasome and keep the inflammasome from forming, which inhibits the production IL-1 and dampening the initiation of the inflammatory cascade. https://www.frontiersin.org/articles/10.3389/fimmu.2019.02783/full

Pomegranate polyphenols

For the inflammatory cytokines we discussed above, IL-1, IL-6 as well as reactive oxygen species – these are produced in tremendous amounts by a white blood cell called a macrophage – if you can imagine an immune cell that acted like an elite infantry unit, that would be the macrophage. They are highly trained shock troops of the immune system, infiltrating into any territory to annihilate the enemy.

That’s great for an infection, but it’s bad when that happens inside your arteries.

And that’s why we want to support proper macrophage functioning with supplementation of Pomegranate polyphenols.

Some research with Pomegranate polyphenols suggest they can shift macrophages from inflaming the artery wall and initial studies demonstrate that pomegranate extract may encourage the macrophages to chill out and become anti-inflammatory – fighting against the inflammation ravaging your body (https://iubmb.onlinelibrary.wiley.com/doi/full/10.1002/biof.1199)

Alpha Lipoic Acid

Published in the esteemed journal, Circulation, when alpha-lipoic acid was given to metabolic syndrome patients for four weeks, it was shown to decrease the presence of IL-6 in the plasma by 15% - but not only that – it also improved flow-mediated vasodilation of the brachial artery by 44%.

Turmeric: Curcumin

This bright yellow root, in the same family as ginger, has been used in India for centuries as colorful spice, but it’s recently taken the world by storm for it’s reported health benefits.  One of the compounds within Turmeric, known as Curcumin has taken the lion’s share of attention because of it’s potent anti-oxidant content and promotion of a healthy immune response – and we’re excited to include in our powerhouse of support for proper immune function.

Vitamin D, Pomegranate Extract, Turmeric: Curcumin & Alpha Lipoic Acid

At Maduronol we provide a broad approach to supporting your immune health and these ingredients are powerful on their own, but taken together, give you coordinated support to combating systemic immune activation and irritation.

Support Healthy Blood Sugar and Insulin Levels Already within Normal Ranges

Cinnamon Extract, Chromium, Biotin, Alpha Lipoic Acid

 This is one of those issues rarely talked about, but the nicotine from the tobacco can actually cause  a significant lowering of insulin sensitivity.

Insulin is what your pancreas produces so your liver, muscles and other organs can absorb and use all that sugar you are eating.  When you become insulin resistant, you can’t pull that sugar out of the blood anymore.  The increase of sugar in the blood drives inflammation by directly activating immune receptors on the blood vessels and immune cells – making your body think you have an infection - driving an avalanche of inflammation.  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4193767/ and https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2570406/

Maduronol offers powerful metabolism support with Cinnamon Extract, Chromium, Biotin and Alpha Lipoic Acid

Alpha lipoic acid can be found in the mitochondria – the energy factory of cells – and it is a vital co-factor for many enzymes that convert fat and sugar to energy.  It’s been postulated to promote cellular energy production by increasing the speed and efficiency at which cells can pull sugar from the blood and turn it into energy.

Then we add Chromium – an important trace element to the formula. A deficiency in Chromium can cause impaired insulin function, low energy and impaired protein production – and chromium loss is highly associated with the typical American diet of refined foods and simple sugars.  

(https://www.sciencedirect.com/topics/medicine-and-dentistry/chromium-deficiency)

Shawn M. Talbot, Kerry Hughes. The Health Professionals Guide to Dietary Supplements, Lippincott Williams & Wilkins 2007

And finally we round out the metabolism support with Cinnamon Extract and Biotin, to ensure well balanced support of metabolism for sugar, protein and fat – which can help maintain healthy blood sugar and insulin levels already within normal range.