1. Nicotine Increases Your Heart Rate & Constricts Blood Vessels
With that first draw from your stogie, nicotine (up to 50 TIMES more nicotine in a cigar compared to a cigarette) rampages across the membranes in your mouth and directly into your blood stream, putting a vice grip on your coronary arteries – increasing your blood pressure (5-10 mm Hg) and your heart rate (10 -15 beats per minute).
But what if I don’t inhale?… You don’t have to… cigarettes are very acidic (pH 5.3) and the nicotine doesn’t absorb well through the mouth, but cigars are alkaline (pH 8.5), and large amounts of nicotine absorb rapidly through the oral mucosa and into the bloodstream.
2. Vessel Constriction & Oxidation Damages the Lining of Your Arteries
This gives a beating to your blood vessels, causing direct damage to the inner lining of your arteries. This inner lining is called the endothelium, and it produces the nitric oxide which allows the vessels to relax and dilate. This increase in blood vessel damage causes a reduction in the production of nitric oxide while tobacco combustion products and nicotine prepare for the 3rd attack.
3. 100 Quadrillion Free Radicals – Per Puff – Oxidize DNA & Cholesterol
100,000,000,000,000,000 (10^17) free radicals invade your body with EVERY SINGLE PUFF of that cigar. They invade like a horde of locusts – damaging DNA, oxidizing (it’s like rust on iron) everything in their path, but the worst are the damaged cholesterol particles. These oxidized LDL particles act like demonic sticky bombs attached to your already damaged arteries. They burrow their way deep into the lining of the arteries in your heart, making your body think there’s an infection.
4. Oxidized Cholesterol Embeds in the Arteries – Activating the Immune System
Your immune system responds with inflammation by activating immune cells and sending these white blood cells to infiltrate your blood vessels and attempt to get to destroy the oxidized cholesterol “invaders”.
5. The Oxidative Damage Reduces The Body’s Sensitivity to Insulin
Cigar smoking causes one to be less responsive to the insulin produced by your pancreas, meaning the sugar floating around in your blood can’t get into the muscles and other organs that need it.
6. The Reduced Insulin Sensitivity Creates Inflammation In Your Arteries
As blood sugar increases, your body sees increased sugar in the blood as a warning flare for infection. Thinking you have a systemic infection, your body panics and throws the inflammatory response into overdrive, pouring inflammatory cells and signals into your arteries.
Designed for maximum potency, Maduronol provides an encompassing approach to cardiovascular health and support:
Just one dose a day puts you back in control of your body with a sophisticated nutritional formula.
Coenzyme Q10 - Alpha Lipoic Acid - Green Tea Extract - Vitamin C & EAntioxidants use electrons like the way a gun uses bullets. Antioxidants will ‘fire’ electrons at oxidizing particles, stabilizing them, relieving the oxidative onslaught. This works great – until you run out of bullets. As a gun runs out of bullets, antioxidants can run out of electrons. So, they need to be recharged or else will be converted to an oxidative enemy. Meaning Vitamin C, once depleted of electrons, can itself become a powerful oxidizing agent of destruction. That’s why you need a cross-functional team of antioxidants that can re-charge and encourage one another when the going gets tough.
Maduronol has Five Unique and High Performing Antioxidants Specifically Chosen to Support and Recharge One AnotherVitamin C – ascorbic acid – operates within the liquid portions of your body to limit oxidative damage. Vitamin C is directly depleted by cigar smoking, so it is imperative to supplement with Vitamin C, but it needs some help and support. Vitamin E – mixed tocopherols – this is Vitamin C’s partner in crime. These two patrol together looking for oxidizing particles to eradicate. Some clinical studies have even shown that Vitamin C supplementation can prevent the depletion of Vitamin E in smokers. While Vitamin C & E most definitely can recharge each other to fight oxidative damage, we’ve added another ingredient for additional support.
Alpha Lipoic Acid – ALA – is a powerful antioxidant that is both water and fat soluble - meaning it can move through cell wells, assisting Vitamin C and Vitamin E by increasing the exchange of electrons and recharging their ability to fight off oxidative damage.And not only is ALA recharging Vitamin C and Vitamin E, but it is able to support the production of glutathione. Glutathione is your body’s way of pulling out the “antioxidant big guns” as studies show it can not only donate electrons to eliminate oxidative enemies but also directly scavenge the metals in the body that create the oxidative damage. The fourth element in this coordinated counterattack to oxidative damage is Green Tea extract. A single cup of green tea has an antioxidant activity greater than a serving of strawberries, broccoli, or spinach.
The special extract in Maduronol contains a large portion of polyphenols called catechins. These catechins, specifically epigallocatechin (EGCC), are 25 - 100 TIMES more powerful than Vitamins C & E in antioxidant activity.This finally leads to the piston that drives the creation of energy for every cell of your body. This powerful molecule, ConzymeQ10 (Ubiquinone), is a formidable antioxidant. The creation of cellular energy naturally creates free radicals and CoQ10 is part of the cellular machinery that can stop these free radicals in their tracks. And if you’re taking a Statin drug or past the age of 20, your natural levels of CoQ10 are already declining... the use of tobacco just piles on the damage.
Coenzyme Q10 - Alpha Lipoic Acid - Green Tea Extract… Vitamin C & EThis all-star team of natural ingredients was specially formulated to support the antioxidant needs of your cigar smoking self.
That’s why Maduronol uses three powerful and synergistic compounds to support circulation, blood vessel health and endothelial function: Red Grape Seed & Red Grape Skin Extract, Alpha Lipoic Acid & Green Tea ExtractThe polyphenols found in red wine are derived from grape seed and skin during the fermentation process. These compounds have an amazing effect on the dilation of blood vessels – even while smoking. Published in the Journal of the American College of Nutrition, this study took healthy volunteers and had them smoke a single cigarette – which induced immediate and significant vessel constriction (a decrease in flow mediated dilation, FMD) which remained significantly decreased for an entire hour after the single cigarette. But if a participant drank de-alcoholized red wine or regular red wine while smoking the single cigarette, the flow mediated dilation was preserved and unchanged. To quote the study conclusions: “The observed endothelial dysfunction following smoking of one cigarette was counterbalanced by consumption of either red wine or dealcoholized red wine in healthy smokers.” This means the effect of the red wine (with or without alcohol) was so strong that the researchers couldn’t tell the difference between the smokers and non-smokers. The research showed that something in red wine, besides the alcohol, was causing the vessels to remain flexible and dilate - even in the presence of smoking.
This was a mystery until another group discovered the secret: the polyphenols from red grapes that are found in red wine actively bind to the estrogen receptors on the endothelium of blood vessels and induce the cells to continue producing nitric oxide.Now we haven't figured out to how to get red wine into pill form, but what we can do is extract polyphenols from the skin and seeds of red grapes. This powerful method of extraction is how Maduronol can include 200mg of red grape polyphenols - the same as glass of red wine. The second ingredient in our powerhouse of blood vessel support is Alpha Lipoic Acid, which may offer tremendous aid in the support of endothelial function. Researchers from the Boston School of Medicine and the Linus Pauling Institute at Oregon State University showed that the combination of alpha Lipoic Acid and Vitamin C could directly induce human endothelial aortic cells to produce nitric oxide. Another clinical study even reported potential benefits outside the realm of blood vessel support with reported improvements in BMI, HbA1C, total cholesterol and triglycerides. With these studies and many others, we are proud to include ALA as a work horse for the support of endothelial function and blood vessel health. The final pillar for blood vessel support is our Green Tea Extract. While being consumed for many years in Asian cultures, we're beginning understand many of the health benefits of Green Tea. One study, published in the journal HEART, "Green Tea Reverses Endothelial Dysfunction in Healthy Smokers" details how smokers who also drank green tea prior to evaluation “suggest that green tea consumption improved endothelium dependent vasodilatation.” Now we can't put much liquid green tea into a pill, but what we can do is dry the leaves and extract many of the phenolic compounds (like flavanols and catechins) to give you a concentrated dose. And as added bonus to blood vessel support, an analysis of over 1,100 subjects in randomized clinical trials was reported in the American Journal of Clinical Nutrition. They reported that Green Tea extract significantly reduced both Total Cholesterol and LDL-Cholesterol from the serum of fasting patients. For these reasons and many more, Maduronol uses a broad extract of polyphenols and catechins from Green Tea leaf to ensure maximal support of your endothelial function and overall health.
To combat systemic inflammation, Maduronol uses six powerful ingredients to support a healthy anti-inflammatory response: Coenzyme Q10 - Vitamin D - Pomegranate Extract - Turmeric - Alpha Lipoic Acid
A word from William Singletary, PHD Immuniology
– Creator of Maduronol
As an Immunologist by training and I’ve spent my career studying the immune system and working to understand how inflammation works in our bodies – protecting us from infections… and how it breaks; how inflammation drives heart disease, autoimmune disease and cancer. And I’m also an avid cigar smoker and have been since I was 18. I even had a stocked humidor in college.
But my family history is full of heart disease. My dad had his first heart attack at 48, another at 50 and passed away from a pulmonary embolism at 58 – so with that family history, I was worried what cigars were doing to my health. Early on, I had some advanced testing done (I discuss the testing in detail in my free download, ‘The Cigar Smoker’s Guide to Being Practically Healthy”) and the results were shocking.
At the age of 27, I had the arteries of a 60 year old.
That sure as hell got my attention. Even in my 20’s, inflammation was already laying down plaque in my arteries, driving me toward the same fate as my dad. While this was sobering news, it’s what led me on the path to creating Maduronol.
I simply wasn’t willing to give up cigars. I see them as an integral part of enjoying life. So, I had to take a different approach. I didn’t want to be perfectly healthy… I want to be practically healthy – enjoying my bad habits for as long as possible while minimizing my risks as much as I can.
What you have here are the results of the last five years of my wading through medical journals and cutting edge research to distill for you, a simple way for cigar smokers to fight back against the destructive, inflammation-causing effects of cigars through nutritional supplementation, advanced testing and an anti-inflammatory lifestyle.
That’s why I want to offer you a pdf copy of my book, “The Cigar Smoker’s Guide to Being ‘Practically’ Healthy”
Everyone is unique, and without the testing I recommend in the download, most will have no idea what your risk is to have heart attack or stroke… It could be the next ten years, ten minutes or possibly never… but you’ve got to get checked to know.
– Dr. Will Singletary, PHD
*The statements on this website have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
All content found on the Maduronol.com website, including: text, images, audio, or other formats were created for informational purposes only. The content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read on this Website. Maduronol does not recommend or endorse any specific tests, physicians, products, procedures, opinions, or other information that may be mentioned on Maduronol.com.